hereditary parkinsonism syndrome

parkinsonism is used to describe a syndrome manifested by any combination of six cardinal features: tremor at rest, rigidity, bradykinesia, loss of postural reflexes, flexed posture and the freezing. decreased dopaminergic neurotransmission in the basal ganglia is the core biochemical pathology in parkinsonism. hereditary parkinsonism includes various heredodegenerative diseases such as hallervorden-spatz disease, huntingtons disease, lubag (x-linked dystonia-parkinsonism), mitochondrial cytopathies with striatal necrosis, neuroacanthocytosis and wilsons disease. in addition, both autosomal dominant and autosomal recessive forms of the parkinsons disease have been described. in this review, we will introduce these syndromes.